Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning

Abstract Complex signalling between the apical ectodermal ridge (AER - a thickening of the distal epithelium) and the mesoderm controls limb patterning along the proximo-distal axis (humerus to digits). However, the essential in vivo requirement for AER-Fgf signalling makes it difficult to understan...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Sofia Sedas Perez, Caitlin McQueen, Holly Stainton, Joseph Pickering, Kavitha Chinnaiya, Patricia Saiz-Lopez, Marysia Placzek, Maria A. Ros, Matthew Towers
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-09-01
Online Access:	https://doi.org/10.1038/s41467-023-41457-6