Clinical, mechanistic, biomarker, and therapeutic advances in GBA1-associated Parkinson’s disease

Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease. The development of PD is closely linked to genetic and environmental factors, with GBA1 variants being the most common genetic risk. Mutations in the GBA1 gene lead to reduced activity of the coded enzyme, glucoce...

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Bibliographic Details

Published in:	Translational Neurodegeneration
Main Authors:	Xuxiang Zhang, Heng Wu, Beisha Tang, Jifeng Guo
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Gaucher’s disease Parkinson’s disease Glucocerebrosidase Mechanisms Biomarker Therapy
Online Access:	https://doi.org/10.1186/s40035-024-00437-6