Exosomes derived from senescent skeletal muscle cells aggravate nucleus pulposus cell metabolic dysregulation via p38MAPK pathway for promoting intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IVDD) is the primary pathological driver of chronic low back pain. While the mechanical role of skeletal muscle in spinal stability is well-established, its paracrine influence on IVDD—specifically via exosomes—remains poorly understood. This stu...

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Bibliographic Details

Published in:	BMC Musculoskeletal Disorders
Main Authors:	Xiaowei Ma, Weiqi Zhang, Han Yin, Dazhuang Miao, Xianda Gao, Chunxu Fu, Wei Chen, Zhiyong Hou, Qi Zhang, Yingze Zhang, Di Zhang
Format:	Article
Language:	English
Published:	BMC 2026-04-01
Subjects:	Intervertebral disc degeneration Senescent skeletal muscle cells Exosomes Nucleus pulposus cells p38MAPK pathway
Online Access:	https://doi.org/10.1186/s12891-026-09816-8