Impact of anesthetics on rat hippocampus and neocortex: A comprehensive proteomic study based on label-free mass spectrometry

Anesthesia is regarded as an important milestone in medicine. However, the negative effect on memory and learning has been observed. In addition, the impact of anesthetics on postoperative cognitive functions is still discussed. In this work, in vivo experiment simulating a general anesthesia and IC...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	David Astapenko, Marie Vajrychova, Ivo Fabrik, Rudolf Kupcik, Kristyna Pimkova, Vojtech Tambor, Vera Radochova, Vladimir Cerny
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Label-free proteomics Anesthetics Neocortex Hippocampus Long-term potentiation NMDAR
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024036697