Combining metformin with lactate transport inhibitors as a treatment modality for cancer - recommendation proposal

Highly glycolytic cancer cells excrete lactate to maintain cellular homeostasis. Inhibiting lactate export by pharmacological targeting of plasma membrane lactate transporters is being pursued as an anti-cancer therapy. Work from many laboratories show that the simultaneous inhibition of lactate exp...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Don Benjamin, Michael N. Hall
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	cancer metformin monocarboxylate transporter lactic acid MCT4 syrosingopine
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1034397/full