Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway

IntroductionMitochondria dysfunction is one of the primary causes of tubular injury in acute kidney injury (AKI). Notoginsenoside Fc (Fc), a new saponin isolated from Panax notoginseng, exhibited numerous pharmacological actions. However, the beneficial effects of Fc on renal tubular impairment and...

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Published in:	Frontiers in Medicine
Main Authors:	Miaomiao Wei, Yuancheng Gao, Dongsheng Cheng, Haiying Zhang, Wei Zhang, Yilan Shen, Qunwei Huang, Xiaoning An, Bing Wang, Zhonghai Yu, Niansong Wang, Hongbo Chen, Youhua Xu, Dingkun Gui
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	acetaminophen acute kidney injury notoginsenoside Fc mitochondria dysfunction SIRT3/SOD2
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2022.1055252/full