Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone

Abstract DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients t...

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Bibliographic Details

Published in:	npj Genomic Medicine
Main Authors:	Hamza Bakhtiar, Kyle T. Helzer, Yeonhee Park, Yi Chen, Nicholas R. Rydzewski, Matthew L. Bootsma, Yue Shi, Paul M. Harari, Marina Sharifi, Martin Sjöström, Joshua M. Lang, Menggang Yu, Shuang G. Zhao
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-10-01
Online Access:	https://doi.org/10.1038/s41525-022-00328-7