Refining tacrolimus dosing through CYP3A5 pharmacogenetics in Taiwanese renal transplant recipients

Genetic polymorphisms in CYP3A5 affects tacrolimus (Tac) bioavailability; however the optimal genotype-guided starting dose remains undefined. This retrospective cohort study examined the effects of the CYP3A5 allele on Tac pharmacokinetics in 431 Taiwanese renal transplant recipients. Genotyping wa...

書目詳細資料
發表在:	Renal Failure
Main Authors:	Yen-Lin Chang, Tzu-Hung Hsiao, Yi-Ming Chen, Ching-Heng Lin, Yi-Ju Liao, Chiann-Yi Hsu, Yung‑Po Liaw, Cheng-Hsu Chen
格式:	Article
語言:	英语
出版:	Taylor & Francis Group 2025-12-01
主題:	Tacrolimus CYP3A5 pharmacogenetics taiwanese population Renal transplantation
在線閱讀:	https://www.tandfonline.com/doi/10.1080/0886022X.2025.2523567

相似書籍

Progress in pharmacogenetic studies on effect on tacrolimus concentrations
由: YANG Shuang, et al.
出版: (2020-01-01)

Impact of CYP3A4 and CYP3A5 polymorphisms on tacrolimus dose requirements in Saudi kidney transplant patients
由: Marzog S. Al Nasser, et al.
出版: (2025-08-01)

Insights into the Pharmacogenetics of Tacrolimus Pharmacokinetics and Pharmacodynamics
由: Mercè Brunet, et al.
出版: (2022-08-01)

Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients
由: C Wheeler, et al.
出版: (2024-04-01)

Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation
由: Alexandra D. Ladd, et al.
出版: (2025-07-01)

Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese
由: Chien-Chou Hou, et al.
出版: (2021-08-01)

The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center
由: Emaad Abdel-Kahaar, et al.
出版: (2019-09-01)

CYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatment
由: Chen L, et al.
出版: (2018-03-01)

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients
由: Lesly Yanira Xajil-Ramos, et al.
出版: (2025-05-01)

Genetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients
由: Cheng F, et al.
出版: (2021-11-01)

Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
由: Qian Li, et al.
出版: (2021-07-01)

Influence of Genetic Polymorphisms in CYP3A5, CYP3A4, and MDR1 on Tacrolimus Metabolism after kidney transplantation
由: Mirgul Bayanova, et al.
出版: (2024-04-01)

The pharmacogenetics antiepileptic drugs
由: N. A. Shnayder, et al.
出版: (2008-12-01)

Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients
由: Daniel A. Brazeau, et al.
出版: (2020-08-01)

THE SIGNIFICANCE OF PHARMACOGENETIC CYP2C19 TESTING FOR PERSONALIZATION OF THE ANTIPLATELET THERAPY IN CARDIOLOGY PRACTICE
由: K. B. Mirzaev, et al.
出版: (2015-09-01)

Favorable Results of Concomitant Tacrolimus and Sirolimus Therapy in Taiwanese Renal Transplant Recipients at 12 Months
由: Kuo-Hsin Chen, et al.
出版: (2008-07-01)

Impact of combined CYP3A4 and CYP3A5 single- nucleotide polymorphisms on tacrolimus exposure and acute rejection in Egyptian pediatric kidney transplant recipients: single center experience
由: Fatina I. Fadel, et al.
出版: (2025-09-01)

Influence of Cyp3A4, Cyp3A5 and ABCB1 polymorphisms on tacrolimus concentrations and rejection risk in Indian kidney transplant recipients
由: Kamal Kiran Mukkavilli, et al.
出版: (2024-01-01)

Association of Metabolic Genotype Composite CYP3A5*3 and CYP3A4*1B to Tacrolimus Pharmacokinetics in Stable Black and White Kidney Transplant Recipients
由: Daniel Brazeau, et al.
出版: (2025-10-01)

Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation
由: Jefferson Antonio Buendía, et al.
出版: (2020-09-01)

Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients
由: Tsvetelin Lukanov, et al.
出版: (2022-12-01)

Use of Pharmacogenetics to Optimize Immunosuppressant Therapy in Kidney-Transplanted Patients
由: Valentina Urzì Brancati, et al.
出版: (2022-07-01)

Recipient Versus Donor CYP3A4/5 Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant
由: Eda Eken, et al.
出版: (2025-09-01)

Effect of cytochrome P450 3A5 polymorphism on the pharmacokinetics of tacrolimus in renal transplant recipients
由: Yi Yi Htun, et al.
出版: (2020-03-01)

Genetic polymorphisms of CYP2B6*6, CYP2C8*3 and CYP2D6*4 in vivax malaria patients from Brazilian Amazon
由: José Pereira de Moura Neto, et al.
出版: (2023-11-01)

From genes to drugs: CYP2C19 and pharmacogenetics in clinical practice
由: Qamar Shubbar, et al.
出版: (2024-02-01)

Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration
由: Yoshiyuki Ohno, et al.
出版: (2023-12-01)

Pharmacogenomic Analysis of CYP3A5&ast;3 and Tacrolimus Trough Concentrations in Vietnamese Renal Transplant Outcomes
由: Nguyen TVA, et al.
出版: (2024-02-01)

Clinical and safety outcomes of conversion original tacrolimus to generic tacrolimus in Turkish kidney transplant recipients
由: Emrah Günay
出版: (2020-09-01)

A Robust and Fast/Multiplex Pharmacogenetics Assay to Simultaneously Analyze 17 Clinically Relevant Genetic Polymorphisms in <i>CYP3A4</i>, <i>CYP3A5</i>, <i>CYP1A2</i>, <i>CYP2C9</i>, <i>CYP2C19</i>, <i>CYP2D6</i>, <i>ABCB1,</i> and <i>VKORC1</i> Genes
由: Camille Tron, et al.
出版: (2022-05-01)

Interaction between tacrolimus and calcium channel blockers based on CYP3A5 genotype in Chinese renal transplant recipients
由: Huiying Zong, et al.
出版: (2024-08-01)

Acute pharmacogenetic dystonic reactions in a family with the CYP2D6 *41 allele: a case report
由: Darice Y. Wong, et al.
出版: (2021-08-01)

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.
由: Santosh ePhilips, et al.
出版: (2012-03-01)

CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients
由: Yilei Yang, et al.
出版: (2021-07-01)

Effects of <i>CYP3A5</i> Genotypes on Thrombocytopenia in Liver Transplantation Patients Treated with Tacrolimus
由: Zhe Guo, et al.
出版: (2023-11-01)

Importance of Pharmacogenetics and Drug–Drug Interactions in a Kidney Transplanted Patient
由: Julia Concha, et al.
出版: (2023-07-01)

Pharmacogenetic testing of allelic variants of the CYP2D6 gene in hormone positive breast cancer
由: L. N. Lyubchenko, et al.
出版: (2017-10-01)

Pharmacogenetics of warfarin: A literature review
由: Nadezhda V. Izmozherova, et al.
出版: (2024-11-01)

Individualized tacrolimus therapy: Insights from CYP3A5 polymorphisms and intestinal metabolism
由: Mizuki Mishima, et al.
出版: (2024-09-01)

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients
由: Erica Fernanda Lindarte, et al.
出版: (2025-03-01)