Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis

Abstract SPI1 was recently reported as a genetic risk factor for Alzheimer’s disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have therapeutic benefits. To investigate the effect of modulating SPI1 levels on AD p...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Byungwook Kim, Luke Child Dabin, Mason Douglas Tate, Hande Karahan, Ahmad Daniel Sharify, Dominic J. Acri, Md Mamun Al-Amin, Stéphanie Philtjens, Daniel Curtis Smith, H. R. Sagara Wijeratne, Jung Hyun Park, Mathias Jucker, Jungsu Kim
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-48484-x