Impact of CYP3A4 functional variability on ziprasidone metabolism

IntroductionZiprasidone is primarily metabolized by CYP3A4, an enzyme with genetic variability and susceptibility to inhibition or induction. This study explored the functional variability of CYP3A4 in ziprasidone metabolism, focusing on drug interactions and genetic polymorphisms.MethodsThe metabol...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Qi Zhou, Yameng Wu, Zhize Ye, Zheyan Zhang, Kai Zheng, Jianchang Qian, Zhongxiang Xiao, Yang Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	ziprasidone quercetin drug-drug interaction CYP3A4 LC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1585040/full