Quantitative 1H-NMR spectroscopy identifies metabolites and lipoprotein subclasses associated with intermediate phenotypes of chronic diseases in the Japanese Nagahama Study

Abstract Metabolomics is a powerful molecular phenotyping technology which can be used in population studies to identify metabolites underlying disease conditions. To identify plasma biomarkers potentially predicting chronic diseases we applied 1H nuclear magnetic resonance (NMR) metabolomics using...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Huiting Ou, Shuji Kawaguchi, François Brial, Kazuhiro Sonomura, Takahisa Kawaguchi, Andrée E. Gravel, Sanjoy Kumar Das, Daniel Auld, Yasuharu Tabara, Bertrand J. Jean-Claude, Mark Lathrop, Fumihiko Matsuda, Dominique Gauguier
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	Biomarker Lipoproteins Phenome-Wide Association NMR
Online Access:	https://doi.org/10.1038/s41598-025-12305-y