Clinical and mutational profiles of adult medulloblastoma groups

Abstract Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We performed molecular grouping, targeted sequencing, and TERT promoter Sanger sequencing on a cohort of 99 adult medulloblastomas. SHH made up 50% of the cohort, whereas Group 3 (13%) was present in com...

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Bibliographic Details
Published in:Acta Neuropathologica Communications
Main Authors: Gabriel Chun-Hei Wong, Kay Ka-Wai Li, Wei-Wei Wang, Anthony Pak-Yin Liu, Queenie Junqi Huang, Aden Ka-Yin Chan, Manix Fung-Man Poon, Nellie Yuk-Fei Chung, Queenie Hoi-Wing Wong, Hong Chen, Danny Tat Ming Chan, Xian-Zhi Liu, Ying Mao, Zhen-Yu Zhang, Zhi-Feng Shi, Ho-Keung Ng
Format: Article
Language:English
Published: BMC 2020-11-01
Subjects:
Adult medulloblastoma
Molecular group
Targeted sequencing
TP53
MYC
KMT2C
Online Access:http://link.springer.com/article/10.1186/s40478-020-01066-6

Internet

http://link.springer.com/article/10.1186/s40478-020-01066-6

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