Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication

ABSTRACT Porcine epidemic diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. The host factors required for PEDV replication, including receptors, remain poorly understood. Here, we...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Yu Zhao, Guanghao Guo, Yumei Sun, Mengjia Zhang, Gan Yang, Zhongzhu Liu, Yanbin Song, Ahmed H. Ghonaim, Ningning Ma, Mengdi Zhang, Anan Jongkaewwattana, Qigai He, Wentao Li
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-08-01
Subjects:	Porcine epidemic diarrhea virus CRISPR/Cas9 RPSA ERK1/2 pathway lipid metabolism aminopeptidase N
Online Access:	https://journals.asm.org/doi/10.1128/jvi.00649-25