UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

Abstract Background Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initia...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Brittney S. Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W. Caminear, Lidia F. Hernandez, Donna Butcher, Elijah F. Edmondson, Nadia Traficante, Joy Hendley, Australian Ovarian Cancer Study, Madeline Gough, Rebecca Rogers, Rohan Lourie, Jyoti Shetty, Bao Tran, Fathi Elloumi, Abdalla Abdelmaksoud, Madhu Lal Nag, Krystyna Mazan-Mamczarz, Carrie D. House, John D. Hooper, Christina M. Annunziata
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	UGDH Ovarian cancer Molecular subtypes Mesenchymal Tumor microenvironment
Online Access:	https://doi.org/10.1186/s13046-023-02820-z