Silencing p75NTR prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina

Accumulation of the nerve growth factor precursor (proNGF) and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplored. This study seeks to investigate the mechanism...

Full description

Bibliographic Details
Published in:	Molecular Therapy: Methods & Clinical Development
Main Authors:	Ahmed Y Shanab, Barbara A Mysona, Suraporn Matragoon, Azza B El-Remessy
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050116300250

Similar Items

The expression system affects the binding affinity between p75NTR and proNGF
by: Mami Hino, et al.
Published: (2024-07-01)

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR
by: Erika Kropf, et al.
Published: (2023-11-01)

Conformational plasticity of proNGF.
by: Francesca Paoletti, et al.
Published: (2011-01-01)

p75, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
by: Melissa W. VonDran, et al.
Published: (2014-09-01)

ProNGF/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells
by: Valentina Pallottini, et al.
Published: (2020-10-01)

ProNGF and Neurodegeneration in Alzheimer’s Disease
by: Margaret Fahnestock, et al.
Published: (2019-02-01)

The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR
by: Sonia Covaceuszach, et al.
Published: (2023-02-01)

High-frequency repetitive transcranial magnetic stimulation protects against 6-OHDA-induced Parkinson’s disease symptoms by modulating the proNGF-p75NTR-sortilin pathway
by: Rui Zhao, et al.
Published: (2025-07-01)

ProNGF processing in adult rat tissues and bioactivity of NGF prodomain peptides
by: Marie Anne Makoudjou, et al.
Published: (2024-04-01)

Characterization of NGF, trkANGFR, and p75NTR in Retina of Mice Lacking Reelin Glycoprotein
by: Bijorn Omar Balzamino, et al.
Published: (2014-01-01)

NGF and proNGF reciprocal interference in immunoassays : open questions, criticalities and ways forward
by: Francesca Malerba, et al.
Published: (2016-08-01)

Cerebrospinal fluid level of proNGF as potential diagnostic biomarker in patients with frontotemporal dementia
by: Francesca Malerba, et al.
Published: (2024-01-01)

NGF and proNGF regulate functionally distinct mRNAs in PC12 cells: an early gene expression profiling.
by: Mara D'Onofrio, et al.
Published: (2011-01-01)

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats
by: Ashley M. Fortress, et al.
Published: (2011-01-01)

Retraction: Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway.
by: PLOS ONE Editors
Published: (2017-01-01)

Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats
by: Wang Tao, et al.
Published: (2012-02-01)

p75NTR regulates postnatal skeletal development via NGF-responsive JNK signaling
by: Chiho Kadota-Watanabe, et al.
Published: (2025-09-01)

The Effect of Interaction NGF/p75<sup>NTR</sup> in Sperm Cells: A Rabbit Model
by: Cesare Castellini, et al.
Published: (2022-03-01)

QS8: The Roles of the TrkA and p75NTR NGF Receptors in Corneal Wound Healing
by: Kiana Tajdaran, et al.
Published: (2021-07-01)

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.
by: Pablo F Barcelona, et al.
Published: (2018-01-01)

Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease
by: Erika Kropf, et al.
Published: (2021-08-01)

Expression of nerve growth factor (NGF), TrkA and p75NTR in developing human foetal teeth
by: Thimios A. Mitsiadis, et al.
Published: (2016-08-01)

NGF and P75NTR gene expression is associated with the hepatic fibrosis stage due to viral and non-viral causes.
by: Ednelza da Silva Graça Amoras, et al.
Published: (2015-01-01)

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells
by: Julien Cicero, et al.
Published: (2023-12-01)

Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats
by: Zhifeng Wu, et al.
Published: (2024-03-01)

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade
by: Sara Negrini, et al.
Published: (2013-07-01)

Up-Regulation of ProBDNF/p75NTR Signaling in Spinal Cord Drives Inflammatory Pain in Male Rats
by: Li H, et al.
Published: (2023-01-01)

Structural characterization of the self-association of the death domain of p75(NTR.).
by: Qianhui Qu, et al.
Published: (2013-01-01)

Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA: Possible Role in Proliferative Diabetic Retinopathy
by: Sally L. Elshaer, et al.
Published: (2013-01-01)

p75NTR Modulation Reduces Oxidative Stress and the Expression of Pro-Inflammatory Mediators in a Cell Model of Rett Syndrome
by: Michela Varone, et al.
Published: (2024-11-01)

p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway
by: Qingli Lu, et al.
Published: (2021-01-01)

Dysregulation of proBDNF/p75NTR and BDNF/TrkB Signaling in Acute Ischemic Stroke: Different Sides of the Same Coins
by: Hala Alnoaman, et al.
Published: (2025-06-01)

Acellular ex vivo lung perfusate silences pro-inflammatory signaling in human lung endothelial and epithelial cells
by: Jamie E. Jeon, et al.
Published: (2023-10-01)

Hippocampal exosomes from stroke aggravate post-stroke depression by regulating the expression of proBDNF and p75NTR and altering spine density
by: Sheng Huang, et al.
Published: (2024-11-01)

BDNF-TrkB/proBDNF-p75NTR pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats
by: Danting Jia, et al.
Published: (2023-10-01)

A review of studies on the roles of p75NTR in the tooth development and tissue regeneration
by: Shi-Ting LI, et al.
Published: (2020-10-01)

Overexpression of p75<sup>NTR</sup> in Human Seminoma: A New Biomarker?
by: Anna Perri, et al.
Published: (2021-06-01)

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells
by: Joanna Bandoła, et al.
Published: (2017-08-01)

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
by: Nádia P. Gonçalves, et al.
Published: (2019-05-01)

SorCS3 promotes the internalization of p75NTR to inhibit GBM progression
by: Yanqiu Zhang, et al.
Published: (2022-04-01)