Genetic variants of AcrAB and OqxAB and the impact of efflux pump inhibition on ciprofloxacin and amikacin resistance in clinical isolates of Klebsiella pneumoniae from Lima, Peru

Abstract Background Klebsiella pneumoniae is a World Health Organization priority pathogen because of its rapidly accumulating resistance to multiple drug classes. Over-expression of the AcrAB and OqxAB Resistance-Nodulation-Division (RND) efflux pumps is a key mechanism, yet genomic data on these s...

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Bibliographic Details
Published in:BMC Microbiology
Main Authors: Deysi Aguilar-Luis, Wilmer Silva-Caso, Giancarlo Pérez-Lazo, Liliana Morales-Castillo, Marta Camps, Fernando Soto-Febres, Miguel Angel Aguilar-Luis, Ronald Aquino-Ortega, Juana del Valle-Mendoza
Format: Article
Language:English
Published: BMC 2026-03-01
Subjects:
Efflux pump
Klebsiella pneumoniae
Inhibitors of efflux pumps
Online Access:https://doi.org/10.1186/s12866-026-04847-6

Internet

https://doi.org/10.1186/s12866-026-04847-6

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