Aroclor 1254 induced inhibitory effects on osteoblast differentiation in murine MC3T3-E1 cells through oxidative stress

This study aimed to evaluate the osteotoxicity of polychlorinated biphenyls in murine osteoblastic MC3T3-E1 cells, and to explore the underlying mechanism focused on oxidative stress. The cells were exposed to Aroclor 1254 at concentrations of 2.5-20 µmol/L, and then cell viability, oxidative stress...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Yu Chen, Yuwei Cai, Chunxiang Chen, Mengting Li, Lingdan Lu, Zhongxiang Yu, Shuqiang Wang, Lei Fang, Shengming Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	MC3T3-E1 cell Aroclor 1254 oxidative stress calcium homeostasis osteoblast differentiation
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2022.940624/full