Type A asparagine synthetase in the zoonotic Cryptosporidium parvum (CpAsnA): Biochemical features and potential as a novel therapeutic target

Cryptosporidium parvum is an intestinal protozoan parasite, the causative agent of the diarrheal cryptosporidiosis in humans and animals for which fully effective treatments are yet unavailable. The C. parvum genome encodes highly streamlined metabolic pathways, lacking enzymes to synthesize any ami...

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Bibliographic Details

Published in:	International Journal for Parasitology: Drugs and Drug Resistance
Main Authors:	Zongzhen Zhai, Peng Jiang, Dongqiang Wang, Tao Chen, Jigang Yin, Guan Zhu
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Subjects:	Apicomplexans Cryptosporidium parvum Type A asparagine synthase (ASNS-A or AsnA) Drug target Thermal shift assay (TSA) Anti-cryptosporidial efficacy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320725000247