The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques, we show that the flexible, N-terminal domain of Pr...

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Bibliographic Details

Published in:	eLife
Main Authors:	Bei Wu, Alex J McDonald, Kathleen Markham, Celeste B Rich, Kyle P McHugh, Jörg Tatzelt, David W Colby, Glenn L Millhauser, David A Harris
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-05-01
Subjects:	neurotoxicity prion protein regulation
Online Access:	https://elifesciences.org/articles/23473