Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB^0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives

SLC6A14 (ATB^0,+) is unique among SLC proteins in its ability to transport 18 of the 20 proteinogenic (dipolar and cationic) amino acids and naturally occurring and synthetic analogues (including anti-viral prodrugs and nitric oxide synthase (NOS) inhibitors). SLC6A14 mediates...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Catriona M. H. Anderson, Noel Edwards, Andrew K. Watson, Mike Althaus, David T. Thwaites
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Subjects:	amino acid transporter solute carrier SLC membrane transport SLC6A14 SLC6
Online Access:	https://www.mdpi.com/2218-273X/12/10/1404