Virus detection by short read high throughput sequencing in a high virus low cellular background

Abstract The safety of all biological products includes demonstrating the absence of adventitious viruses by testing various types of samples at different stages of the manufacturing process. Seven laboratories evaluated short-read high-throughput sequencing (HTS) for sensitivity and breadth of adve...

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Bibliographic Details

Published in:	npj Vaccines
Main Authors:	Pei-Ju Chin, Christophe Lambert, Pascale Beurdelay, Robert L. Charlebois, Anne-Sophie Colinet, Marc Eloit, Shanaz Gilchrist, Maria Gilleece, Matthew Hess, Andreas Leimbach, Tom J. B. de Man, Olivier Vandeputte, Dawid Walas, Weihong Wang, Arifa S. Khan
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s41541-025-01104-1