Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium

Streptococcus pneumoniae (pneumococcus) is an opportunistic pathogen that remains the leading cause of bacterial meningitis worldwide. For meningitis to occur, pneumococcus must breach the blood-brain barrier (BBB), a highly specialized network of brain endothelial cells that comprise the microvascu...

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Bibliographic Details

Published in:	Virulence
Main Authors:	Henry D. Mauser, Taryn E. Keyzer, Jessica M. Surma, Natalie G. Alexander, William D. Cutts, Sarah F. Hathcock, Kimberly H. Lackey, Daryl W. Lam, Justin A. Thornton, Nadine Vollmuth, Brandon J. Kim
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Streptococcus pneumoniae blood-brain barrier pneumococcal meningitis brain endothelial cells iPSC-BEC
Online Access:	https://www.tandfonline.com/doi/10.1080/21505594.2025.2564281