To recruit or to graft? Comparing the recruitment of resident non-neuronal cells by lineage reprogramming with engraftment of stem cell-derived neurons for neuronal replacement therapies

Neurons are post-mitotic cells that are not replaced once lost, leading to the need for neuronal replacement therapies for central nervous system (CNS) repair. The generation of induced pluripotent stem cell (iPSC) derived human neurons is relatively advanced, with the capacity to generate pure and...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Author:	Daniel A. Peterson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	lineage reprogramming stem cell therapeutics cell grafting gene therapy neural repair and regeneration CNS repair
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1589790/full