Lysosome stress response and mitochondria injury are the earliest detectable alteration in FSGS

Abstract Focal segmental glomerulosclerosis (FSGS) is a histopathologic lesion caused by a dysfunction and loss of podocytes. Podocytes as postmitotic cells, rely on lysosomes to maintain their structural and functional integrity and on mitochondria to adapt their metabolic needs. The importance of...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Eileen Dahlke, Jessica Promnitz, Mairon Trujillo Miranda, Makhabbat Saudenova, Gèraldine Mollet, Franziska Theilig
Format: Article
Language:English
Published: Nature Portfolio 2025-10-01
Subjects:
Lysosome stress
Mitochondria injury
Podocyte
FSGS
Online Access:https://doi.org/10.1038/s41598-025-22622-x

Internet

https://doi.org/10.1038/s41598-025-22622-x

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