Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin

Eukaryotic pre-mRNA is processed by a large multiprotein complex to accurately cleave the 3′ end, and to catalyse the addition of the poly(A) tail. Within this cleavage and polyadenylation specificity factor (CPSF) machinery, the CPSF73/CPSF3 endonuclease subunit directly contacts both CPSF100/CPSF2...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Stéphane Thore, Finaritra Raoelijaona, Vincent Talenton, Sébastien Fribourg, Cameron D. Mackereth
Format:	Article
Language:	English
Published:	The Royal Society 2023-11-01
Subjects:	protein structure pre-mRNA processing NMR spectroscopy cleavage and polyadenylation specificity factor
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.230221