Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort

Abstract Background Common variants have explained less than the amount of heritability expected for complex diseases, which has led to interest in less-common variants and more powerful approaches to the analysis of whole-genome scans. Because of low frequency (low statistical power), less-common v...

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Bibliographic Details

Published in:	BMC Genomics
Main Authors:	John Cologne, Lenora Loo, Yurii B. Shvetsov, Munechika Misumi, Philip Lin, Christopher A. Haiman, Lynne R. Wilkens, Loïc Le Marchand
Format:	Article
Language:	English
Published:	BMC 2018-07-01
Subjects:	Colorectal cancer Genome-wide association study Metabochip array Multiethnic Cohort SNP set analysis
Online Access:	http://link.springer.com/article/10.1186/s12864-018-4910-8