A defect in mitochondrial protein translation influences mitonuclear communication in the heart

The heart requires high levels of mitochondria to sustain function, and mitochondrial stressors can be transmitted to the nucleus and reprogram metabolism. Here, the authors show that a mitochondrial ribosomal protein is important for heart development in mice by increasing nuclear Klf15 expression.

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Feng Gao, Tian Liang, Yao Wei Lu, Xuyang Fu, Xiaoxuan Dong, Linbin Pu, Tingting Hong, Yuxia Zhou, Yu Zhang, Ning Liu, Feng Zhang, Jianming Liu, Andrea P. Malizia, Hong Yu, Wei Zhu, Douglas B. Cowan, Hong Chen, Xinyang Hu, John D. Mably, Jian’an Wang, Da-Zhi Wang, Jinghai Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Online Access:	https://doi.org/10.1038/s41467-023-37291-5