Establishment of CD34 + hematopoietic stem cell-derived xenograft model of hyperleukocytic acute myeloid leukemia

Abstract Background Hyperleukocytic acute myeloid leukemia (HLL) is marked by high early mortality and presents significant therapeutic challenges. Research on HLL is still in its infancy, and comprehensive development of patient-derived xenograft (PDX) models, especially CD34 + hematopoietic stem c...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Yanxia Jin, Yuxing Liang, Balu Wu, Sanyun Wu, Xiaoyan Liu, Fuling Zhou
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Hyperleukocytic acute myeloid leukemia CD34 + hematopoietic stem cell Patient-derived xenograft model B-NSG mice
Online Access:	https://doi.org/10.1186/s12885-025-13907-5