Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats

Low-frequency stimulation (LFS) has been considered as an option for the treatment of intractable epilepsy. However, previous data showed that LFS of certain brain regions only exerts its effect within a very narrow therapeutic time window, which lasts from seconds to tens of seconds, thus restricti...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Kai Zhong, Deng-Chang Wu, Miao-Miao Jin, Zheng-Hao Xu, Yi Wang, Wei-Wei Hou, Xiao-Ming Li, Shi-Hong Zhang, Zhong Chen
Format:	Article
Language:	English
Published:	Elsevier 2012-10-01
Subjects:	Epilepsy Low-frequency stimulation Kindling seizures Subiculum
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996112001970