Inference of drug off-target effects on cellular signaling using interactome-based deep learning

Summary: Many diseases emerge from dysregulated cellular signaling, and drugs are often designed to target specific signaling proteins. Off-target effects are, however, common and may ultimately result in failed clinical trials. Here we develop a computer model of the cell’s transcriptional response...

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Bibliographic Details

Published in:	iScience
Main Authors:	Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Subjects:	Bioinformatics Biological sciences Health informatics Health sciences Medical informatics Natural sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224007302