Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose

As amorphization may improve the solubility and bioavailability of a drug substance, the aim of this work was to assess to what extent the crystallinity of caffeine (CAF) and theophylline (TF) can be reduced by homogenization with a polymeric excipient. To realize this purpose, the physical mixtures...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Edyta Leyk, Marek Wesolowski
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Subjects:
caffeine
theophylline
HPMC
miscibility curves
solubility curves
DSC
Online Access:https://www.mdpi.com/1999-4923/13/11/1836

Internet

https://www.mdpi.com/1999-4923/13/11/1836

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