Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton

SETD2 is known to be the unique histone methyltransferase responsible for the trimethylation of the lysine 36 of histone H3 thus generating H3K36me3. This epigenetic mark is critical for transcriptional activation and elongation, DNA repair, mRNA splicing, and DNA methylation. Recurrent SETD2-inacti...

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Bibliographic Details

Published in:	Neoplasia: An International Journal for Oncology Research
Main Authors:	Christina Michail, Fernando Rodrigues Lima, Mireille Viguier, Frédérique Deshayes
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Cancer Cytoskeleton Genetic alterations Histones SETD2 Structure
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558624001313