BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21

Abstract Background Diabetic cardiomyopathy (DCM) is one of leading causes of diabetes-associated mortality. The gut microbiota-derived branched-chain amino acids (BCAA) have been reported to play a central role in the onset and progression of DCM, but the potential mechanisms remain elusive. Result...

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Bibliographic Details
Published in:Microbiome
Main Authors: Hong Zheng, Xi Zhang, Chen Li, Die Wang, Yuying Shen, Jiahui Lu, Liangcai Zhao, Xiaokun Li, Hongchang Gao
Format: Article
Language:English
Published: BMC 2024-08-01
Subjects:
BCAA
Diabetes
Fibrosis
Mitochondria
Gut microbiota
Heart
Online Access:https://doi.org/10.1186/s40168-024-01872-3

Internet

https://doi.org/10.1186/s40168-024-01872-3

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