BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21

Abstract Background Diabetic cardiomyopathy (DCM) is one of leading causes of diabetes-associated mortality. The gut microbiota-derived branched-chain amino acids (BCAA) have been reported to play a central role in the onset and progression of DCM, but the potential mechanisms remain elusive. Result...

Full description

Bibliographic Details
Published in:	Microbiome
Main Authors:	Hong Zheng, Xi Zhang, Chen Li, Die Wang, Yuying Shen, Jiahui Lu, Liangcai Zhao, Xiaokun Li, Hongchang Gao
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	BCAA Diabetes Fibrosis Mitochondria Gut microbiota Heart
Online Access:	https://doi.org/10.1186/s40168-024-01872-3

Similar Items

BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM
by: Na Li, et al.
Published: (2023-06-01)

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents
by: Sofia Moran-Ramos, et al.
Published: (2021-09-01)

BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria
by: Klára Gotvaldová, et al.
Published: (2024-03-01)

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
by: Qing-Bo Lu, et al.
Published: (2023-11-01)

Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer
by: Zhenkang Li, et al.
Published: (2025-05-01)

Enhancing recovery from plyometric circuit training: The synergistic impact of dynamic stretching, BCAA supplementation, and sports massage on DOMS
by: Ari Tri Fitrianto, et al.
Published: (2023-10-01)

Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver
by: Maria Camila Trillos-Almanza, et al.
Published: (2024-03-01)

Salivary BCAA, Glutamate, Glutamine and Urea as Potential Indicators of Nitrogen Metabolism Imbalance in Breast Cancer
by: Elena A. Sarf, et al.
Published: (2025-10-01)

Branched-Chain Amino Acids (BCAAs) - oral supplementation and its effects in resistance training and treatment
by: Borys Bieńkowski, et al.
Published: (2023-08-01)

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion
by: Yimeng Chen, et al.
Published: (2025-10-01)

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
by: Xiao Guo, et al.
Published: (2023-02-01)

The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis
by: Huan Tian, et al.
Published: (2024-04-01)

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment
by: Qianquan Ma, et al.
Published: (2025-05-01)

The effect of swimming training and liposomal BCAA supplementation on miR-133 and miR-206 gene expression in soleus muscle mitochondria of aged male rats
by: Amir Hajighasem, et al.
Published: (2024-03-01)

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise
by: Allison Clark, et al.
Published: (2017-05-01)

BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signaling
by: Yi Zhou, et al.
Published: (2025-05-01)

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
by: Veronika Voronova, et al.
Published: (2022-11-01)

FGF21-dependent alleviation of cholestasis-induced liver fibrosis by sodium butyrate
by: Jing Yang, et al.
Published: (2024-07-01)

Loss of Eicosapentaenoic Acid (EPA) after Retort Sterilization of the EPA-BCAA Fortified Complete Nutrition Drink
by: Watcharapol Khoonin, et al.
Published: (2022-07-01)

The effects of BCAA and creatine supplementation on anaerobic capacity and ball kicking speed in male football players
by: Ahmet Mor, et al.
Published: (2021-06-01)

Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC
by: Meiting Xue, et al.
Published: (2023-08-01)

Xanthomonas campestris utilizes IAA to regulate its viability and virulence by altering the production of BCAAs and ROS
by: Sinan Li, et al.
Published: (2025-10-01)

Gut microbiota-mitochondrial crosstalk in obesity: novel mechanistic insights and therapeutic strategies with traditional Chinese medicine
by: Lingmiao Wen, et al.
Published: (2025-04-01)

Amino acids and BCAA composition of Mungbean (Vigna radiata L.) seeds and sprouts for plant-based protein applications
by: Chanwook Kim, et al.
Published: (2025-08-01)

Bioregional Alterations in Gut Microbiome Contribute to the Plasma Metabolomic Changes in Pigs Fed with Inulin
by: Weida Wu, et al.
Published: (2020-01-01)

LncBADR promotes T cell-mediated autoimmunity by binding Mccc1 and Pcca to regulate BCAAs degradation
by: Yanting Lei, et al.
Published: (2025-09-01)

Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance
by: Yang Yang, et al.
Published: (2024-12-01)

Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model
by: Jomana Hatahet, et al.
Published: (2023-02-01)

High Glucose-Induced Cardiomyocyte Death May Be Linked to Unbalanced Branched-Chain Amino Acids and Energy Metabolism
by: Xi Zhang, et al.
Published: (2018-04-01)

BCAA metabolism: the Achilles’ heel of ovarian cancer, polycystic ovary syndrome, and premature ovarian failure
by: Tian Zeng, et al.
Published: (2025-07-01)

Butyric Acid Ameliorates Myocardial Fibrosis by Regulating M1/M2 Polarization of Macrophages and Promoting Recovery of Mitochondrial Function
by: Xiaogang Li, et al.
Published: (2022-05-01)

Crosstalk between Gut Microbiota and Hepatocellular Carcinoma
by: Chencheng Xie, et al.
Published: (2023-04-01)

Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells
by: Ling Huang, et al.
Published: (2025-09-01)

Partial suppression of BCAA catabolism as a potential therapy for BCKDK deficiency
by: Laura Ohl, et al.
Published: (2024-06-01)

Modulating the Gut–Muscle Axis: Increasing SCFA-Producing Gut Microbiota Commensals and Decreasing Endotoxin Production to Mitigate Cancer Cachexia
by: Sagnik Roy, et al.
Published: (2025-06-01)

Gut microbiota and atrial cardiomyopathy
by: Tingting Sun, et al.
Published: (2025-02-01)

Persistent delay in maturation of the developing gut microbiota in infants with cystic fibrosis
by: Adrian J. Verster, et al.
Published: (2025-03-01)

Branched-Chain Amino Acid (BCAA) Oligopeptide Determination from Whey Proteins: Preparation, Peptide Profiles, and Anti-Fatigue Activity
by: Qiong Zhu, et al.
Published: (2024-12-01)

Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism
by: Angela Pochakom, et al.
Published: (2022-06-01)

Metabolic fate of tea polyphenols and their crosstalk with gut microbiota
by: Meiyan Wang, et al.
Published: (2022-05-01)