The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.

The orexin/hypocretin system is important for appetitive motivation towards multiple drugs of abuse, including nicotine. Both OX1 and OX2 receptors individually have been shown to influence nicotine self-administration and reinstatement. Due to the increasing clinical use of dual orexin receptor ant...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Shaun Yon-Seng Khoo, Gavan P McNally, Kelly J Clemens
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Online Access:	http://europepmc.org/articles/PMC5351999?pdf=render