Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages

Abstract We have previously reported the transcriptomic and lipidomic profile of the first-generation, hygromycin-resistant (HygR) version of the BCGΔBCG1419c vaccine candidate, under biofilm conditions. We recently constructed and characterized the efficacy, safety, whole genome sequence, and prote...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mario Alberto Flores-Valdez, Eliza J. R. Peterson, Michel de Jesús Aceves-Sánchez, Nitin S. Baliga, Yasu S. Morita, Ian L. Sparks, Deepak Kumar Saini, Rahul Yadav, Roland Lang, Dulce Mata-Espinosa, Juan Carlos León-Contreras, Rogelio Hernández-Pando
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Subjects:	BCG Tuberculosis RNASeq Transcriptomic c-di-GMP Lipids
Online Access:	https://doi.org/10.1038/s41598-024-61815-8