Plant-Produced Anti-Zika Virus Monoclonal Antibody Glycovariant Exhibits Abrogated Antibody-Dependent Enhancement of Infection

Monoclonal antibodies (mAb) against the envelope (E) protein of Zika virus (ZIKV) have shown great potential as therapeutics against the Zika epidemics. However, their use as a therapy may predispose treated individuals to severe infection by the related dengue virus (DENV) via antibody-dependent en...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Ming Yang, Haiyan Sun, Huafang Lai, Biswas Neupane, Fengwei Bai, Herta Steinkellner, Qiang Chen
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	Zika virus monoclonal antibody (mAb) plant-made antibody antibody dependent enhancement of infection (ADE) antibody-dependent cellular cytotoxicity (ADCC) Fc effector function
Online Access:	https://www.mdpi.com/2076-393X/11/4/755