A Multivalent mRNA Therapeutic Vaccine Exhibits Breakthroughs in Immune Tolerance and Virological Suppression of HBV by Stably Presenting the Pre-S Antigen on the Cell Membrane

<b>Background/Objectives</b>: In chronic hepatitis B infection (CHB), the hepatitis B surface antigen (HBsAg) continuously exhausts the hepatitis B surface antibody (HBsAb), which leads to the formation of immune tolerance. Accordingly, the hepatitis B virus (HBV) infection can be blocke...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Shang Liu, Jie Wang, Yunxuan Li, Muhan Wang, Pei Du, Zhijie Zhang, Wenguo Li, Rongchen Sun, Mingtao Fan, Meijia Yang, Hongping Yin
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	chronic hepatitis B immune tolerance hepatitis B surface antigen mRNA therapeutic vaccines pre-S antigen
Online Access:	https://www.mdpi.com/1999-4923/17/2/211