The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention

The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. While research had initially focused on signal transduction centered on β-catenin as a key effector activating a pro-tumorigenic transcriptional response, nowadays it is known that WNT ligands can also ind...

Full description

Bibliographic Details
Published in:	Cells
Main Authors:	Kerstin Menck, Saskia Heinrichs, Cornelia Baden, Annalen Bleckmann
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	ROR1 ROR2 cancer WNT signaling non-canonical targeted therapy
Online Access:	https://www.mdpi.com/2073-4409/10/1/142

Similar Items

Characterization and impact of non‐canonical WNT signaling on outcomes of urothelial carcinoma
by: Margaret Meagher, et al.
Published: (2024-04-01)

ROR2 receptor promotes the migration of osteosarcoma cells in response to Wnt5a
by: Bin Dai, et al.
Published: (2017-11-01)

WNT5a-ROR Signaling Is Essential for Alveologenesis
by: Changgong Li, et al.
Published: (2020-02-01)

Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein
by: Jie Xian, et al.
Published: (2024-07-01)

CK1ε and p120‐catenin control Ror2 function in noncanonical Wnt signaling
by: Josué Curto, et al.
Published: (2018-05-01)

Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates
by: Michael W Susman, et al.
Published: (2017-09-01)

Pan-Tissue and -Cancer Analysis of ROR1 and ROR2 Transcript Variants Identify Novel Functional Significance for an Alternative Splice Variant of ROR1
by: Miya John, et al.
Published: (2022-10-01)

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
by: Samuel C Griffiths, et al.
Published: (2024-05-01)

Wnt5a/Ror2 promotes vascular smooth muscle cells proliferation via activating PKC
by: Yaning Shi, et al.
Published: (2022-09-01)

Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells
by: Shunjiro Kurihara, et al.
Published: (2024-01-01)

ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells
by: Amineh Ghaderi, et al.
Published: (2020-06-01)

Melatonin nuclear receptors mediate monochromatic light-induced T-lymphocyte proliferation of thymus through the AKT/GSK3β/β-catenin pathway in chick
by: Juanjuan Xiong, et al.
Published: (2024-12-01)

Preclinical development of ozuriftamab vedotin (BA3021), a novel ROR2-specific conditionally active biologic antibody–drug conjugate
by: Hwai Wen Chang, et al.
Published: (2025-12-01)

The signal pathway of melatonin mediates the monochromatic light-induced T-lymphocyte apoptosis in chicken thymus
by: Juanjuan Xiong, et al.
Published: (2024-02-01)

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance
by: José A. Peña-Flores, et al.
Published: (2023-01-01)

Novel humanized monoclonal antibodies against ROR1 for cancer therapy
by: Rong Wei, et al.
Published: (2024-08-01)

Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways
by: Hanna Karvonen, et al.
Published: (2019-08-01)

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells
by: Hind Hussein, et al.
Published: (2020-01-01)

Digoxin, an Overlooked Agonist of RORγ/RORγT
by: Kaja Karaś, et al.
Published: (2019-01-01)

A ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells
by: Amineh Ghaderi, et al.
Published: (2022-10-01)

Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9
by: Lianghai Wang, et al.
Published: (2017-12-01)

Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist
by: Patrik F. Schwarz, et al.
Published: (2022-08-01)

Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway
by: LingLi Hou, et al.
Published: (2018-09-01)

Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity
by: Emily Hams, et al.
Published: (2020-08-01)

Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization
by: Antonio García de Herreros, et al.
Published: (2019-09-01)

The application of machine learning methods to the prediction of novel ligands for RORγ/RORγT receptors
by: Rafał A. Bachorz, et al.
Published: (2023-01-01)

A ROR1 targeted bispecific T cell engager shows high potency in the pre-clinical model of triple negative breast cancer
by: Fan Wang, et al.
Published: (2025-03-01)

Differential Expression Pattern of linc-ROR Spliced Variants in Pluripotent and Non-Pluripotent Cell Lines
by: Fatemeh Mirzadeh Azad, et al.
Published: (2022-10-01)

Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies
by: Yuming Zhao, et al.
Published: (2021-05-01)

Экспрессия ROR-1 в диагностике и мониторинге минимальной остаточной болезни при хроническом лимфолейкозе
by: Евгений Владимирович Почтарь, et al.
Published: (2022-04-01)

Downregulation of ROR2 attenuates LPS‐induced A549 cell injury through JNK and ERK signaling pathways
by: Zhonglin Wang, et al.
Published: (2023-04-01)

Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in Drosophila by repressing the hippo pathway
by: Joseph Bunker, et al.
Published: (2023-03-01)

The roles of Linc-ROR in the regulation of cancer stem cells
by: Xiaoling Wen, et al.
Published: (2023-02-01)

A ROR1 small molecule inhibitor (KAN0441571C) induced significant apoptosis of ibrutinib‐resistant ROR1+ CLL cells
by: Amineh Ghaderi, et al.
Published: (2021-08-01)

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers
by: Yan Pan, et al.
Published: (2016-11-01)

De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells
by: Loélia Babin, et al.
Published: (2022-03-01)

The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells
by: Dongli Liu, et al.
Published: (2022-04-01)

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species
by: Ren Zhou, et al.
Published: (2025-10-01)

Dietary Organic Zinc Supplementation Modifies the Oxidative Genes via RORγ and Epigenetic Regulations in the Ileum of Broiler Chickens Exposed to High-Temperature Stress
by: Saber Y. Adam, et al.
Published: (2024-09-01)

RON, ROR1 and SUSD2 expression in tissues of endometrial carcinoma patients. Clinicopathological and prognostic implications
by: Abeer Abdelbary, et al.
Published: (2022-06-01)