A novel and accurate full-length HTT mouse model for Huntington’s disease

Here, we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using a bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ~226 CAG-CAA repeats and containing endogenous human HTT promoter and regulatory elements. BAC22...

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Bibliographic Details
Published in:eLife
Main Authors: Sushila A Shenoy, Sushuang Zheng, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Jerry Cheng, Wenzhen Duan, Chenjian Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Subjects:
huntington's disease
neurodegeneration
transgenic mouse
brain atrophy
neuron loss
Htt aggregates
Online Access:https://elifesciences.org/articles/70217

Internet

https://elifesciences.org/articles/70217

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