Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation

Abstract Amyloid fibrils are important scaffold in bacterial biofilms. Streptococcus mutans is an established cariogenic bacteria dwelling within biofilms, and C123 segment of P1 protein is known to form amyloid fibrils in S. mutans biofilms, among which C3 segment could serve as a promising anti-am...

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Bibliographic Details

Published in:	AMB Express
Main Authors:	Yuanyuan Chen, Guxin Cui, Yuqi Cui, Dongru Chen, Huancai Lin
Format:	Article
Language:	English
Published:	SpringerOpen 2021-12-01
Subjects:	Amyloid fibrils Streptococcus mutans Biofilm formation Small molecule
Online Access:	https://doi.org/10.1186/s13568-021-01333-2