Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study

Background: Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention. Methods: We chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples and...

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Bibliographic Details

Published in:	eLife
Main Authors:	Avner Ehrlich, Konstantinos Ioannidis, Makram Nasar, Ismaeel Abu Alkian, Yuval Daskal, Nofar Atari, Limor Kliker, Nir Rainy, Matan Hofree, Sigal Shafran Tikva, Inbal Houri, Arrigo Cicero, Chiara Pavanello, Cesare R Sirtori, Jordana B Cohen, Julio A Chirinos, Lisa Deutsch, Merav Cohen, Amichai Gottlieb, Adina Bar-Chaim, Oren Shibolet, Michal Mandelboim, Shlomo L Maayan, Yaakov Nahmias
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-01-01
Subjects:	translational research COVID-19 metabolic regulation drug repurposing
Online Access:	https://elifesciences.org/articles/79946