CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait

Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare concern in swine production. Disrupting porcine KISS1 is hypothesized to delay or abolish puberty by inducing variable hypogonadotrop...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Julio M. Flórez, Kyra Martins, Staci Solin, Jonathan R. Bostrom, Paula Rodríguez-Villamil, Felipe Ongaratto, Sabreena A. Larson, Uyanga Ganbaatar, Alexander W. Coutts, Doug Kern, Thomas W. Murphy, Eui-Soo Kim, Daniel F. Carlson, Abe Huisman, Tad S. Sonstegard, Clay A. Lents
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	kisspeptin pig puberty animal welfare boar taint embryo editing homology-directed repair
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2022.1078991/full