Nanoparticles Based on Quaternary Ammonium Chitosan-methyl-β-cyclodextrin Conjugate for the Neuropeptide Dalargin Delivery to the Central Nervous System: An In Vitro Study

Peptide oral administration is a hard goal to reach, especially if the brain is the target site. The purpose of the present study was to set up a vehicle apt to promote oral absorption of the neuropeptide dalargin (DAL), allowing it to cross the intestinal mucosal barrier, resist enzymatic degradati...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Chiara Migone, Letizia Mattii, Martina Giannasi, Stefania Moscato, Andrea Cesari, Ylenia Zambito, Anna Maria Piras
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Subjects:	mucoadhesive nanoparticles Caco-2 monolayer permeation bEnd.3 monolayer permeation blood–brain barrier permeation peptide brain targeting
Online Access:	https://www.mdpi.com/1999-4923/13/1/5