Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC

Abstract Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models and examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as a key driver of chemoresistance and tumorigenesis, operat...

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Bibliographic Details
Published in:Advanced Science
Main Authors: Xinyuan Zhao, Bing Guo, Wenjuan Sun, Jinhua Yu, Li Cui
Format: Article
Language:English
Published: Wiley 2023-09-01
Subjects:
cholesterol
cisplatin resistance
c‐Myc
lipid raft
squalene epoxidase
Online Access:https://doi.org/10.1002/advs.202206878

Internet

https://doi.org/10.1002/advs.202206878

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