Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway

Abstract The lack of knowledge about the mechanism of hyperoxia-induced intestinal injury has attracted considerable attention, due to the potential for this condition to cause neonatal complications. This study aimed to explore the relationship between hyperoxia-induced oxidative damage and ferropt...

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Yanping Liu, Tianming Li, Changping Niu, Zhengwei Yuan, Siyu Sun, Dongyan Liu
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Hyperoxia Intestinal epithelial cells Ferroptosis COX-2/PGE2/EP2 pathway Inflammatory
Online Access:	https://doi.org/10.1186/s10020-024-00993-7