Modulatory Effect of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) on the 2-Oxoglutarate Mitochondrial Carrier

The 2-oxoglutarate carrier (OGC), pivotal in cellular metabolism, facilitates the exchange of key metabolites between mitochondria and cytosol. This study explores the influence of NADPH on OGC transport activity using proteoliposomes. Experimental data revealed the ability of NADPH to modulate the...

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Bibliographic Details
Published in:Molecules
Main Authors: Anna Spagnoletta, Daniela Valeria Miniero, Nicola Gambacorta, Francesca Oppedisano, Anna De Grassi, Orazio Nicolotti, Ciro Leonardo Pierri, Annalisa De Palma
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Subjects:
mitochondrial transport
oxoglutarate carrier
NADPH regulation
molecular docking
kinetic analysis
isocitrate/oxoglutarate shuttle
Online Access:https://www.mdpi.com/1420-3049/29/21/5154

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https://www.mdpi.com/1420-3049/29/21/5154

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