Synthesis of Novel Biologically Active Proflavine Ureas Designed on the Basis of Predicted Entropy Changes

A novel series of proflavine ureas, derivatives <b>11a</b>–<b>11i</b>, were synthesized on the basis of molecular modeling design studies. The structure of the novel ureas was obtained from the pharmacological model, the parameters of which were determined from studies of the...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ladislav Janovec, Eva Kovacova, Martina Semelakova, Monika Kvakova, Daniel Kupka, David Jager, Maria Kozurkova
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	proflavine ureas molecular design cytostatic activity cytotoxicity
Online Access:	https://www.mdpi.com/1420-3049/26/16/4860