Dysfunction of the neurovascular unit as a temporal driver in Alzheimer’s pathogenesis

Abstract Extensive studies have shown that cerebrovascular dysfunction is a critical factor in the onset and progression of Alzheimer’s disease (AD). Neurovascular unit (NVU) is impaired in AD brains, including damage of tight junction between endothelial cells, degeneration of pericytes, activation...

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Bibliographic Details
Published in:Translational Neurodegeneration
Main Authors: Lifang Wang, Lei Han, Shiping Liu
Format: Article
Language:English
Published: BMC 2026-04-01
Subjects:
Alzheimer’s disease
Neurovascular unit
NVU organoids
Spatial transcriptomics
Online Access:https://doi.org/10.1186/s40035-026-00548-2

Internet

https://doi.org/10.1186/s40035-026-00548-2

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