The 3<i>S</i> Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase. SF2312 can only be synthesized as a racemic-diastereomeric mixture. However, co-crystal...

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发表在:	Molecules
Main Authors:	Federica Pisaneschi, Yu-Hsi Lin, Paul G. Leonard, Nikunj Satani, Victoria C. Yan, Naima Hammoudi, Sudhir Raghavan, Todd M. Link, Dimitra K. Georgiou, Barbara Czako, Florian L. Muller
格式:	文件
语言:	英语
出版:	MDPI AG 2019-07-01
主题:	glycolysis enolase chiral phosphonate hydroxamate <i>E. coli</i> enzyme inhibitor enzyme structure natural product X-ray crystallography
在线阅读:	https://www.mdpi.com/1420-3049/24/13/2510